Two Twenty Two is located at 222 (hey!) Columbus Avenue, just two blocks from the Transamerica Pyramid in San Francisco.


222 Columbus Avenue is between Pacific Avenue and Broadway Street in San Francisco. Please dial #400 on the keypad outside the front door. Take the elevator or stairs to the 4th floor. Two Twenty Two Skin Care is just down the hall on the left.

222 Columbus Avenue is also home to:

Brioche Bakery and Cafe 

Maritime Wine Tasting Studio

Reveille Coffee Company

Dream Masters Custom Tattoos



22 Columbus is a quick stroll from the Montgomery Street BART station and is easily accessible by MUNI lines 8x, 10, 12, 30, 39, 41, and 45.

Parking can be an adventure in San Francisco, and it certainly is in North Beach. Several lots are available within a few blocks, including:

  • 555 Jackson Street at Kearny Street

  • 772 Pacific Avenue at Grant Street

  • 955 Sansome Street at Vallejo Street